Isocyanides in the synthesis of nitrogen heterocycles

AV Lygin, A de Meijere - Angewandte Chemie International …, 2010 - Wiley Online Library
Isocyanides have long proved themselves to be irreplaceable building blocks in modern
organic chemistry. The unique features of the isocyano group make isocyanides particularly …

Neurokinin-1 receptor antagonists: a comprehensive patent survey

SC Huang, VL Korlipara - Expert opinion on therapeutic patents, 2010 - Taylor & Francis
Importance of the field: Substance P is involved in mediating a number of biological effects
such as emesis, pain, inflammation, bronchoconstriction, antitumor activity, and regulation of …

Electrocatalytic Intermolecular C(sp3)–H/N–H Coupling of Methyl N-Heteroaromatics with Amines and Amino Acids: Access to Imidazo-Fused N-Heterocycles

P Qian, Z Yan, Z Zhou, K Hu, J Wang, Z Li, Z Zha… - Organic …, 2018 - ACS Publications
An efficient NH4I-mediated intermolecular annulation of methyl N-heteroaromatics with
amines/amino acids was developed by virtue of anodic oxidation, providing a variety of …

Trifluoromethyl Rhodium‐Carbynoid in [2+ 1+ 2] Cycloadditions

WW Zhao, MY Tian, YL Zhou, LJ Liu… - Angewandte …, 2024 - Wiley Online Library
Trifluoromethyl cationic carbyne (CF3C+:) possessing dual carbene‐carbocation behavior
emulated as trifluoromethyl metal‐carbynoid (CF3C+= M) has not been explored yet, and its …

Cu(I)-Catalyzed Transannulation of N-Heteroaryl Aldehydes or Ketones with Alkylamines via C(sp3)–H Amination

M Li, Y Xie, Y Ye, Y Zou, H Jiang, W Zeng - Organic letters, 2014 - ACS Publications
A copper (I)-catalyzed direct transannulation of N-heteroaryl aldehydes or ketones with
alkylamines via Csp3–H amination has been achieved using molecular oxygen as a sole …

Natural α-Amino Acids Applied in the Synthesis of Imidazo[1,5-a]N-heterocycles under Mild Conditions

Q Wang, S Zhang, F Guo, B Zhang, P Hu… - The Journal of Organic …, 2012 - ACS Publications
A facile iodine-mediated decarboxylative cyclization from α-amino acids and N-heterocyclic
carbaldehydes was developed. By virtue of this method, a series of imidazo [1, 5-a] N …

Isocyanide in der Synthese von Stickstoff‐Heterocyclen

AV Lygin, A de Meijere - Angewandte Chemie, 2010 - Wiley Online Library
Isocyanide bewähren sich seit langem als unersetzliche Bausteine in der modernen
organischen Chemie. Die einzigartigen Eigenschaften der Isocyanogruppe machen …

Diastereoselective Double Annulation of Allenoates with Povarov Adducts: Modular Synthesis of Multisubstituted Pyrroloquinolines

S Yaragorla, D Arun - The Journal of Organic Chemistry, 2024 - ACS Publications
Diastereoselective Double Annulation of Allenoates with Povarov Adducts: Modular Synthesis of
Multisubstituted Pyrroloquinolines | The Journal of Organic Chemistry Recently Viewedclose …

Imidazoquinoline Derivatives as Potential Inhibitors of InhA Enzyme and Mycobacterium tuberculosis

P Hoffmann, J Azéma-Despeyroux, F Goncalves… - Molecules, 2024 - mdpi.com
Tuberculosis is a serious public health problem worldwide. The search for new antibiotics
has become a priority, especially with the emergence of resistant strains. A new family of …

Diversity‐Oriented Metal‐Free Synthesis of Nitrogen‐Containing Heterocycles Using Atropaldehyde Acetals as a Dual C3/C2‐Synthon

S Chen, B You, T Zhang, M Li, Y Gu - ChemSusChem, 2022 - Wiley Online Library
A highly efficient and elegant diversity‐oriented reaction paradigm employing atropaldehyde
acetals as new dual C2/C3 synthons was developed under metal‐free conditions using …