The clinical manifestations, molecular mechanisms and treatment of craniosynostosis
E Stanton, M Urata, JF Chen… - Disease Models & …, 2022 - journals.biologists.com
Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …
A genetic-pathophysiological framework for craniosynostosis
SRF Twigg, AOM Wilkie - The American Journal of Human Genetics, 2015 - cell.com
Craniosynostosis, the premature fusion of one or more cranial sutures of the skull, provides
a paradigm for investigating the interplay of genetic and environmental factors leading to …
a paradigm for investigating the interplay of genetic and environmental factors leading to …
[图书][B] The mathematics and mechanics of biological growth
A Goriely - 2017 - books.google.com
This monograph presents a general mathematical theory for biological growth. It provides
both a conceptual and a technical foundation for the understanding and analysis of …
both a conceptual and a technical foundation for the understanding and analysis of …
Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
Cranial sutures are major growth centers for the calvarial vault, and their premature fusion
leads to a pathologic condition called craniosynostosis. This study investigates whether …
leads to a pathologic condition called craniosynostosis. This study investigates whether …
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes
R Brommage, J Liu, GM Hansen, LL Kirkpatrick… - Bone research, 2014 - nature.com
Screening gene function in vivo is a powerful approach to discover novel drug targets. We
present high-throughput screening (HTS) data for 3 762 distinct global gene knockout (KO) …
present high-throughput screening (HTS) data for 3 762 distinct global gene knockout (KO) …
Global elongation and high shape flexibility as an evolutionary hypothesis of accommodating mammalian brains into skulls
Little is known about how the large brains of mammals are accommodated into the dazzling
diversity of their skulls. It has been suggested that brain shape is influenced by relative brain …
diversity of their skulls. It has been suggested that brain shape is influenced by relative brain …
Computational modelling of patient specific spring assisted lambdoid craniosynostosis correction
Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by
fusion of the lambdoid sutures at the back of the head. Surgical correction including the …
fusion of the lambdoid sutures at the back of the head. Surgical correction including the …
Integration of brain and skull in prenatal mouse models of Apert and Crouzon syndromes
SM Motch Perrine, T Stecko, T Neuberger… - Frontiers in Human …, 2017 - frontiersin.org
The brain and skull represent a complex arrangement of integrated anatomical structures
composed of various cell and tissue types that maintain structural and functional association …
composed of various cell and tissue types that maintain structural and functional association …
Dimensional, geometrical, and physical constraints in skull growth
After birth, the skull grows and remodels in close synchrony with the brain to allow for an
increase in intracranial volume. Increase in skull area is provided primarily by bone …
increase in intracranial volume. Increase in skull area is provided primarily by bone …
Cell mechanics of craniosynostosis
Z Al-Rekabi, ML Cunningham… - … biomaterials science & …, 2017 - ACS Publications
Craniosynostosis is the premature fusion of the calvarial sutures that is associated with a
number of physical and intellectual disabilities spanning from pediatric to adult years. Over …
number of physical and intellectual disabilities spanning from pediatric to adult years. Over …