The intracellular malaria parasites extensively modify host erythrocytes to allow nutrient
uptake, ensure homeostasis, and evade the host's immune response. To achieve this, the …

Variant surface antigens play an important role in Plasmodium falciparum malaria
pathogenesis and in immune evasion by the parasite. Although most work to date has …

Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum.
The pathology of cerebral malaria is characterized by the accumulation of infected …

Sequence diversity in pathogen antigens is an obstacle to the development of interventions
against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 …

Plasmodium falciparum is the protozoan parasite that causes most malaria-associated
morbidity and mortality in humans with over 500,000 deaths annually. The disease …

Background DNA microarrays have been a valuable tool in malaria research for over a
decade but remain in limited use in part due their relatively high cost, poor availability, and …

Middle image: Plasmodium falciparum merozoite invading a red blood cell. Differential
interference contrast (DiC) microscopy image of a merozoite attached to the red blood cell …

Eukaryotic high-mobility-group-box (HMGB) proteins are nuclear factors involved in
chromatin remodeling and transcription regulation. When released into the extracellular …

Babesia microti is a protozoan considered to be a major etiological agent of emerging
human babesiosis. It imposes an increasing public-health threat and can be overlooked …

The regulation of variant gene expression in Plasmodium falciparum is still only partially
understood. Regulation of var genes, the most studied gene family involved in antigenic …