Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of
diseases with different clinical manifestations including cutaneous, mucocutaneous and …

Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Highlights•Six computational methods for water molecule placement and analysis reviewed
alongside relevant case studies.•Field is approaching maturity.•Adoption into mainstream …

The SZMAP method computes binding free energies and the corresponding thermodynamic
components for water molecules in the binding site of a protein structure [SZMAP, 1.0. 0; …

Leishmania mexicana has a large family of cyclin‐dependent kinases (CDKs) that reflect the
complex interplay between cell cycle and life cycle progression. Evidence from previous …

Curcumin is the major phenolic compound found in turmeric, a dry powder of rhizomes and
roots of the plant, Curcuma longa L., which is widely used as spice and food colorant around …

Highlights•Visceral leishmaniasis is a complicated infectious disease.•Emerging resistance
is one of the main complications in treatment visceral leishmaniasis.•A comprehensive …

Existing therapies for leishmaniases present significant limitations, such as toxic side effects,
and are rendered inefficient by parasite resistance. It is of utmost importance to develop …

Introduction: Indirubins are bisindole alkaloids naturally occurring in indigo-bearing plants or
in mollusks from the Muricidae family. They belong to the rather small family of indigoids …

Leishmania parasites are thought to control protein activity at the post-translational level, eg
by protein phosphorylation. In the pathogenic amastigote, the mammalian stage of …