Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Predisposing and precipitating factors associated with delirium: a systematic review

CH Ormseth, SC LaHue, MA Oldham… - JAMA network …, 2023 - jamanetwork.com
Importance Despite discrete etiologies leading to delirium, it is treated as a common end
point in hospital and in clinical trials, and delirium research may be hampered by the attempt …

Delirium in elderly people

SK Inouye, RGJ Westendorp, JS Saczynski - The lancet, 2014 - thelancet.com
Delirium is an acute disorder of attention and cognition in elderly people (ie, those aged 65
years or older) that is common, serious, costly, under-recognised, and often fatal. A formal …

Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health

BP O'Gara, L Gao, ER Marcantonio… - Anesthesiology, 2021 - pubs.asahq.org
The prevention of perioperative neurocognitive disorders is a priority for patients, families,
clinicians, and researchers. Given the multiple risk factors present throughout the …

Incidence, predictive factors, and effect of delirium after transcatheter aortic valve replacement

M Abawi, F Nijhoff, P Agostoni… - JACC: Cardiovascular …, 2016 - jacc.org
Objectives: The purpose of this study was to investigate the incidence, predictive factors, and
effect of post-operative delirium (POD) among patients treated by transcatheter aortic valve …

Ibudilast attenuates folic acid–induced acute kidney injury by blocking pyroptosis through TLR4-mediated NF-κB and MAPK signaling pathways

X Li, Y Zou, YY Fu, J Xing, KY Wang, PZ Wan… - Frontiers in …, 2021 - frontiersin.org
Folic acid (FA)-induced renal tubule damage, which is characterized by extensive
inflammation, is a common model of acute kidney injury (AKI). Pyroptosis, a pro …

A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Curcumin (Curcuma longa), Boswellia (Boswellia serrata), and French …

EK Donovan, S Kekes-Szabo, JC Lin… - International Journal of …, 2021 - mdpi.com
This report is part of a larger study designed to rapidly and efficiently screen potential
treatments for Gulf War Illness (GWI) by testing nine different botanicals. In this placebo …

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as prognostic predictors for delirium in critically ill patients: a systematic review and meta-analysis

S Sarejloo, N Shojaei, B Lucke-Wold… - BMC …, 2023 - Springer
Introduction In this systematic review and meta-analysis, we aim to analyze the current
literature to evaluate neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio …

Toll-like receptor 4 knockout ameliorates neuroinflammation due to lung-brain interaction in mechanically ventilated mice

T Chen, C Chen, Z Zhang, Y Zou, M Peng… - Brain, Behavior, and …, 2016 - Elsevier
Abstract Toll-like receptor 4 (TLR4) is a crucial receptor in the innate immune system, and
increasing evidence supports its role in inflammation, stress, and tissue injury, including …

Peri-and postoperative cognitive and consecutive functional problems of elderly patients

A Müller, G Lachmann, A Wolf, R Mörgeli… - Current opinion in …, 2016 - journals.lww.com
Especially in elderly patients, postoperative delirium constitutes a common, severe
complication. Early diagnosis and supportive treatment are essential to improve outcome. To …