Most lymphocytes express cell surface Ag receptor chains from single alleles of distinct Ig or
TCR loci. Since the identification of Ag receptor allelic exclusion, the importance of this …

T cells play critical role in multiple immune processes including antigen response, tumor
immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver …

The monoallelic expression of antigen receptor (AgR) genes, called allelic exclusion, is
fundamental for highly specific immune responses to pathogens. This cardinal feature of …

Allelic exclusion of immunoglobulin (Ig) and T-cell receptor (TCR) genes ensures the
development of B and T lymphocytes operating under the mode of clonal selection. This …

The adaptive immune system endows mammals with an ability to recognize nearly any
foreign invader through antigen receptors that are expressed on the surface of all …

The lifelong generation of αβT cells enables us to continuously build immunity against
pathogens and malignancies despite the loss of thymic function with age. Homeostatic …

In jawed vertebrates, adaptive immunity depends on the process of V (D) J recombination
creating vast numbers of T and B lymphocytes that each expresses unique Ag receptors of …

V (D) J recombination assembles antigen receptor genes from germline V, D and J
segments during lymphocyte development. In αβT-cells, this leads to the subsequent …

Mammalian cells are thought to protect themselves and their host organisms from DNA
double strand breaks (DSBs) through universal mechanisms that restrain cellular …

Thymus is an important primary lymphoid organ for T cell development. After T-lineage
commitment, the early thymic progenitors (ETPs) develop into CD4− CD8−(DN), CD4+ …