The prevalence of obesity in combination with sarcopenia (the age-related loss of muscle
mass and strength or physical function) is increasing in adults aged 65 years and older. A …

Background Endogenous sex hormones are important for metabolic health in men and
women. Before menopause, women are protected from atherosclerotic cardiovascular …

Background The cardiovascular safety of testosterone-replacement therapy in middle-aged
and older men with hypogonadism has not been determined. Methods In a multicenter …

Abstract Objective To update the “Testosterone Therapy in Men With Androgen Deficiency
Syndromes” guideline published in 2010. Participants The participants include an Endocrine …

OBJECTIVES To develop an evidence‐based definition of sarcopenia that can facilitate
identification of older adults at risk for clinically relevant outcomes (eg, self‐reported mobility …

Purpose: There has been a marked increase in testosterone prescriptions in the past
decade resulting in a growing need to give practicing clinicians proper guidance on the …

Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …

As the world's population ages, the prevalence of chronic diseases increases. Sarcopenia
and osteoporosis are two conditions that are associated with aging, with similar risk factors …

During aging and menopausal transition in women, a progressive muscle degeneration (ie
decrease in quality and muscle function) occurs. This muscle dysfunction, caused by …

Background Serum testosterone concentrations decrease as men age, but benefits of
raising testosterone levels in older men have not been established. Methods We assigned …