The emergence of proteomics, the large-scale analysis of proteins, has been inspired by the
realization that the final product of a gene is inherently more complex and closer to function …

The genome sequence of an organism is an information resource unlike any that biologists
have previously had access to. But the value of the genome is only as good as its …

Quantitative proteome profiling using stable isotope protein tagging and automated tandem
mass spectrometry (MS/MS) is an emerging technology with great potential for the functional …

A new matrix-assisted laser-desorption/ionization time-of-flight/time-of-flight mass
spectrometer with the novel" LIFT" technique (MALDI LIFT-TOF/TOF MS) is described. This …

Current methodologies for protein quantitation include 2-dimensional gel electrophoresis
techniques, metabolic labeling, and stable isotope labeling methods to name only a few …

Using an integrated genomic and proteomic approach, we have investigated the effects of
carbon source perturbation on steady-state gene expression in the yeast Saccharomyces …

The objective of this study was to determine if liquid chromatography mass spectrometry
(LC/MS) data of tryptic digests of proteins can be used for quantitation. In theory, the peak …

In this report, we describe an approach for identification and relative quantitation of
individual proteins within mixtures using LC/MS/MS analysis of protein digests. First, the …

Stable isotope labelling in combination with mass spectrometry has emerged as a powerful
tool to identify and relatively quantify thousands of proteins within complex protein mixtures …

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-Tof-MS)
has recently become a popular and versatile method to analyze macromolecules from …