In mammals, miRNAs recognize target mRNAs via base pairing, which leads to a complex
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …

MicroRNAs (miRNAs) post-transcriptionally repress gene expression by guiding Argonaute
(AGO) proteins to target mRNAs. While much is known about the regulation of miRNA …

MicroRNAs (miRNAs) typically direct degradation of their mRNA targets. However, some
targets have unusual miRNA-binding sites that direct degradation of cognate miRNAs …

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

The regulation of miRNAs is critical to the definition of cell identity and behavior in normal
physiology and disease. To date, the dynamics of miRNA degradation and the mechanisms …

Eukaryotic mRNAs are subject to multiple types of tailing that critically influence mRNA
stability and translatability. To investigate RNA tails at the genomic scale, we previously …

Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly,
piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling …

MicroRNAs (miRNAs) are major drivers of cell fate specification and differentiation. The post-
transcriptional regulation of key molecular factors by microRNAs contributes to the …

MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-
specific RNase III enzyme. By cleaving primary miRNAs (pri-miRNAs) at specific positions …

Small RNAs play important roles in early embryonic development. However, their
expression dynamics and modifications are poorly understood because of the scarcity of …