Carcinogenic N-nitrosamine contamination in certain drugs has recently caused great
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …

Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …

The incidence and spatial distribution of polycyclic aromatic hydrocarbons (PAHs) in the
Buffalo River Estuary in the Eastern Cape Province of South Africa were assessed in this …

Breast cancer is an increasing public health problem. Substantial advances have been
made in the treatment of breast cancer, but the introduction of methods to predict women at …

Investigations on the impact of chemicals on the environment and human health have led to
the development of an exposome concept. The exposome refers to the totality of exposures …

Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …

Under physiological conditions, cells are in a stable state known as redox homeostasis,
which is maintained by the balance between continuous ROS/RNS generation and several …

A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …

Metabolomics, along with other “omics” approaches, is rapidly becoming one of the major
approaches aimed at understanding the organization and dynamics of metabolic networks …

The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …