Accurate quantitative analysis of endogenous analytes is essential for several clinical and
non-clinical applications. LC–MS/MS is the technique of choice for quantitative analyses …

Chromatographic methods are increasingly being used for the quantitative determination of
endogenous compounds in biological samples. This article presents an overview of the …

Identification of pharmaceutical impurities is a critical analytical activity in the drug
development process whose goal is to fully elucidate the chemical structures of unknown …

Sugars and sugar polyols are relatively abundant groups of water-soluble constituents in
atmospheric aerosols. This paper describes a method that uses liquid chromatography …

Hair cortisol levels are increasingly applied as a measure for stress in humans and
mammals. Cortisol is an endogenous compound and is always present within the hair …

The quantification of eicosanoids and their metabolites in biological samples remain an
analytical challenge, even though a number of methodologies/techniques have been …

Rationale Electrospray ionization (ESI) and atmospheric pressure chemical ionization
(APCI) are both used to generate ions for the analysis of metabolites by liquid …

The use of LC–MS for bioanalysis of pharmaceuticals is entering its third decade and may
be considered to be a mature technology. In many respects this is true, considering the …

A bioanalytical method for determining endogenous d-serine levels in the mouse brain
using a surrogate analyte and liquid chromatography–tandem mass spectrometry (LC …

Our previous research demonstrated that milk production of early lactation dairy cows
benefits from postruminally delivered B vitamins in addition to those supplied in rumen …