Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

Abstract Although IL-34 and CSF-1 share actions as key mediators of monocytes/
macrophages survival and differentiation, they also display differences that should be …

Microglia serve as the innate immune cells of the central nervous system (CNS) by providing
continuous surveillance of the CNS microenvironment and initiating defense mechanisms to …

Background: A randomized, placebo-controlled phase III study (AB10015) previously
demonstrated that orally administered masitinib (4.5 mg/kg/day) slowed rate of functional …

Rosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular
mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female …

Although macrophages (MΦ) are known to play a central role in neuropathic pain, their
contribution to cancer pain has not been established. Here we report that depletion of sciatic …

Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by the degeneration and
death of motor neurons. Systemic neuroinflammation contributes to the pathogenesis of …

Although traditionally seen as regulators of hematopoiesis, colony-stimulating factors (CSFs)
have emerged as important players in the nervous system, both in health and disease. This …

Perineural invasion (PNI) driven by the tumor microenvironment (TME) has emerged as a
key pattern of metastasis of prostate cancer (PCa), while its underlying mechanism is still …