The reaction of oxy hemoglobin with nitrite: Mechanism, antioxidant-modulated effect, and implications for blood substitute evaluation
The autocatalytic reaction between nitrite and the oxy form of globins involves free radicals.
For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was …
For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was …
Protein-based blood substitutes: recent attempts at controlling pro-oxidant reactivity with and beyond hemoglobin
Reviewed here are recent attempts to produce protein-based artificial oxygen carriers
(“blood substitutes”). Most of these involve chemical or physical modifications on …
(“blood substitutes”). Most of these involve chemical or physical modifications on …
Oxidative protection of hemoglobin and hemerythrin by cross-linking with a nonheme iron peroxidase: potentially improved oxygen carriers for use in blood substitutes
The nonheme peroxidase, rubrerythrin, shows the ability to reduce hydrogen peroxide to
water without involving strongly oxidizing and free-radical-creating powerful oxidants such …
water without involving strongly oxidizing and free-radical-creating powerful oxidants such …
Titanium dioxide nanotube films: Preparation, characterization and electrochemical biosensitivity towards alkaline phosphatase
I Roman, RD Trusca, ML Soare, C Fratila… - Materials Science and …, 2014 - Elsevier
Titania nanotubes (TNTs) were prepared by anodization on different substrates (titanium,
Ti6Al4V and Ti6Al7Nb alloys) in ethylene glycol and glycerol. The influence of the applied …
Ti6Al4V and Ti6Al7Nb alloys) in ethylene glycol and glycerol. The influence of the applied …
Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts
AD Andreicuț, E Fischer-Fodor… - Oxidative medicine …, 2019 - Wiley Online Library
The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional
medicine, recently gained visibility in the literature, and the activity of several active …
medicine, recently gained visibility in the literature, and the activity of several active …
Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their
differences in prooxidative and physiological reactivity, were compared in terms of the …
differences in prooxidative and physiological reactivity, were compared in terms of the …
Novel Thiazolo[5,4-b]phenothiazine Derivatives: Synthesis, Structural Characterization, and In Vitro Evaluation of Antiproliferative Activity against Human Leukaemia
The molecular frame of the reported series of new polyheterocyclic compounds was
intended to combine the potent phenothiazine and benzothiazole pharmacophoric units …
intended to combine the potent phenothiazine and benzothiazole pharmacophoric units …
In vivo evaluation of hemerythrin-based oxygen carriers: Similarities with hemoglobin-based counterparts
We have previously proposed the annelid-derived protein, hemerythrin, as a viable
replacement for hemoglobin in the synthesis of semi-synthetic oxygen carriers (“blood …
replacement for hemoglobin in the synthesis of semi-synthetic oxygen carriers (“blood …
[HTML][HTML] Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells
M Bota, E Fischer‑Fodor… - Experimental and …, 2019 - spandidos-publications.com
Infantile hemangioma is one of the most common benign tumors affecting children, with~ 10‑
15% requiring medical treatment. These tumors consist of endothelial cells and stromal …
15% requiring medical treatment. These tumors consist of endothelial cells and stromal …
Glutaraldehyde‐Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models
Hemoglobin‐(Hb‐) based oxygen carriers (HBOC) have for several decades been explored
for treatment of hemorrhage. In our previous top‐up tests, HBOC with lower in vitro …
for treatment of hemorrhage. In our previous top‐up tests, HBOC with lower in vitro …