The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …

Radiation therapy has been used worldwide for many decades as a therapeutic regimen for
the treatment of different types of cancer. Just over 50% of cancer patients are treated with …

Castration-resistant prostate cancer (CRPC) presents significant challenges in clinical
management due to its resistance to conventional androgen receptor (AR)-targeting …

Cancer has become a prominent cause of death, accounting for approximately 10 million
deaths worldwide as per the World Health Organization report 2020. Epigenetics deal with …

BRG1 is one of two catalytic subunits of the SWI/SNF ATP-dependent chromatin-remodeling
complex. In cancer, it has been hypothesized that BRG1 acts as a tumor suppressor. Further …

Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …

Simple Summary Chromatin and epigenetic alterations in cancer are responsible for a wide
range of transcriptional changes that link DNA mutations to tumor phenotype. In this review …

Abstract Treatment of prostate cancer confronts resistance to androgen receptor (AR)-
targeted therapies. AR-associated coregulators and chromatin proteins hold a great …

Ovarian tumor (OTU) subfamily deubiquitinases are involved in various cellular processes,
such as inflammation, ferroptosis and tumorigenesis; however, their pathological roles in …

Despite advancements in chemotherapy and the availability of novel therapies, the outcome
of adult patients with B-cell acute lymphoblastic leukemia (B-ALL) remains unsatisfactory …