Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …

Age-related hearing loss is the most common sensory disorder worldwide that contributes to
numerous health conditions in the aging population. Despite its prevalence, current …

Abstract Background Cochlear implants (CIs) restore hearing to deafened patients. The
foreign body response (FBR) following cochlear implantation (post-CI) comprises an …

Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and
nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney …

Abstract Adeno-associated virus (AAV)-mediated inner ear gene therapy is a promising
treatment option for hearing loss and dizziness. Several studies have shown that AAV …

Acute noise-induced loss of synapses between inner hair cells (IHCs) and auditory nerve
fibers (ANFs) has been documented in several strains of mice, but the extent of post …

Noise-induced cochlear synaptopathy is characterized by irreversible loss of synapses
between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) despite normal hearing …

Understanding the complex pathologies associated with hearing loss is a significant
motivation for conducting inner ear research. Lifelong exposure to loud noise, ototoxic …

Background Age-related hearing loss (ARHL)—also termed presbycusis—is prevalent
among older adults, leading to a range of issues. Although considerable progress in the …

Introduction Macrophages are essential immune cells in the cochlea that contribute to
inflammation, tissue repair, and homeostasis. They also play an important role in local …