Epigenetics of male infertility: the role of DNA methylation

JC Rotondo, C Lanzillotti, C Mazziotta… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Consequences of paternal nutrition on offspring health and disease

P Dimofski, D Meyre, N Dreumont, B Leininger-Muller - Nutrients, 2021 - mdpi.com
It is well established that the maternal diet during the periconceptional period affects the
progeny's health. A growing body of evidence suggests that the paternal diet also influences …

Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity

YH Jung, HLV Wang, D Ruiz… - Proceedings of the …, 2022 - National Acad Sciences
The mechanisms by which environmentally-induced epiphenotypes are transmitted
transgenerationally in mammals are poorly understood. Here we show that exposure of …

Bisphenol A-induced epigenetic changes and its effects on the male reproductive system

F Cariati, L Carbone, A Conforti, F Bagnulo… - Frontiers in …, 2020 - frontiersin.org
Bisphenol A (BPA) is a widespread chemical agent which can exert detrimental effects on
the male reproductive system. Exposure to BPA has been shown to induce several …

The epigenetics of gametes and early embryos and potential long-range consequences in livestock species—filling in the picture with epigenomic analyses

L Zhu, SL Marjani, Z Jiang - Frontiers in Genetics, 2021 - frontiersin.org
The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA
methylation, histone modifications, chromatin remodeling, and non-coding RNA species …

Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review

R Sciorio, L Tramontano, M Adel, S Fleming - Journal of Personalized …, 2024 - mdpi.com
Semen quality represents a compelling factor for fertility, and delineating the normal values
has proven difficult. In the last four decades, several authors have reported a noticeable …

Could the sperm epigenome become a diagnostic tool for evaluation of the infertile man?

E Caroppo, MK Skinner - Human Reproduction, 2024 - academic.oup.com
Although male infertility is currently diagnosed when abnormal sperm parameters are found,
the poor predictive ability of sperm parameters on natural fecundity and medically assisted …

Bisphenol A damages testicular junctional proteins transgenerationally in mice

EO Adegoke, MS Rahman, S Amjad, WK Pang… - Environmental …, 2022 - Elsevier
Testicular junctions are pivotal to male fertility and regulated by constituent proteins.
Increasing evidence suggests that environmental chemicals, including bisphenol A (BPA) …

Paternal diet induces transgenerational epigenetic inheritance of DNA methylation signatures and phenotypes in sheep model

CU Braz, T Taylor, H Namous, J Townsend… - PNAS …, 2022 - academic.oup.com
Transgenerational epigenetic inheritance (TEI) requires transmission of environmentally
induced epigenetic changes and associated phenotypes to subsequent generations without …

Long noncoding RNAs: recent insights into their role in male infertility and their potential as biomarkers and therapeutic targets

S Zhao, N Heng, B Weldegebriall Sahlu… - International Journal of …, 2021 - mdpi.com
Long noncoding RNAs (lncRNAs) are composed of nucleotides located in the nucleus and
cytoplasm; these are transcribed by RNA polymerase II and are greater than 200 nt in …