Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate
acute wound healing and long-term tissue remodeling with scarring. With myocardial …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Ferroptosis is an iron-dependent form of regulated cell death, which is characterized by a
large amount of lipid peroxide accumulation and the imbalance of redox state in cells …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Background & Aims We studied the role of interleukin 11 (IL11) signaling in the
pathogenesis of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs) …

Although it is well established that hepatic macrophages play a crucial role in the
development of liver fibrosis, the underlying mechanisms remain largely elusive. Moreover …

The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …

One year of treatment with entecavir (0.5 mg daily) in nucleoside‐naive patients with
hepatitis B e antigen (HBeAg)‐positive or HBeAg‐negative chronic hepatitis B (CHB) …