Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …

Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …

Stimulator of interferon genes (STING) has been shown to be critical for controlling antiviral
responses as well as anti-tumor adaptive immunity, but little is known regarding its …

Colon tumors arise in a stepwise fashion from either discrete genetic perturbations or
epigenetic dysregulation. To uncover the key epigenetic regulators that drive colon cancer …

Human colorectal cancer stem cells (CSCs) are tumour initiating cells that can self-renew
and are highly tumorigenic and chemoresistant. While genetic mutations associated with …

Aging is a progressive process that results in the accumulation of intra-and extracellular
alterations that in turn contribute to a reduction in health. Age-related changes in DNA …

The intestinal epithelium undergoes a continual process of proliferation, differentiation and
apoptosis. Previously, we have shown that the PI3K/Akt/mTOR pathway has a critical role in …

New strategies are being investigated to ameliorate the efficacy and reduce the toxicity of
the drugs currently used in colorectal cancer (CRC), one of the most common malignancies …

Colorectal cancer, a leading cause of mortality worldwide, is a multistep disorder that results
from the alteration of genetic and epigenetic mechanisms under contextual influence …

Abnormal glycosylation due to dysregulated glycosyltransferases and glycosidases is a key
phenomenon of many malignancies, including colorectal cancer (CRC). In particular …