[HTML][HTML] The emerging tools for precisely manipulating microtubules

YL Lian, YC Lin - Current Opinion in Cell Biology, 2024 - Elsevier
Cells generate a highly diverse microtubule network to carry out different activities. This
network is comprised of distinct tubulin isotypes, tubulins with different post-translational …

Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy

W Liu, S He, X Ma, C Lv, H Gu, J Cao, J Du… - Angewandte …, 2024 - Wiley Online Library
Near‐infrared photosensitizers are valuable tools to improve treatment depth in
photodynamic therapy (PDT). However, their low singlet oxygen (1O2) generation ability …

Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy

S Abyar, L Huang, Y Husiev, L Bretin… - Journal of Medicinal …, 2024 - ACS Publications
Photoactivated chemotherapy agents form a new branch of physically targeted anticancer
agents with potentially lower systemic side effects for patients. On the other hand, limited …

Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics

H Shi, RC Marchi, PJ Sadler - Angewandte Chemie, 2025 - Wiley Online Library
Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and
new mechanisms of action to combat resistance to current therapy. We highlight recent …

Microtubule-Targeting NAP Peptide-Ru (II)-polypyridyl Conjugate As a Bimodal Therapeutic Agent for Triple Negative Breast Carcinoma

A Chatterjee, S Sarkar, S Bhattacharjee… - Journal of the …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) poses significant treatment challenges due to its high
metastasis, heterogeneity, and poor biomarker expression. The N-terminus of an …

Bioluminescence Resonance Energy Transfer (BRET)-Mediated Protein Release from Self-Illuminating Photoresponsive Biomaterials

TL Rapp, I Kopyeva, A Adhikari… - Journal of the American …, 2024 - ACS Publications
Phototriggered release of various cargos, including soluble protein factors and small
molecules, has the potential to correct aberrant biological events by offering spatiotemporal …

Cyclic Ruthenium-Peptide Prodrugs Penetrate the Blood–Brain Barrier and Attack Glioblastoma upon Light Activation in Orthotopic Zebrafish Tumor Models

L Zhang, G Zhao, T Dalrymple, Y Husiev… - ACS Central …, 2024 - ACS Publications
The blood–brain barrier (BBB) presents one of the main obstacles to delivering anticancer
drugs in glioblastoma. Herein, we investigated the potential of a series of cyclic ruthenium …

Photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles to impact ATP metabolism

RJ Mitchell, D Havrylyuk, AC Hachey, DK Heidary… - Chemical …, 2025 - pubs.rsc.org
Energy is essential for all life, and mammalian cells generate and store energy in the form of
ATP by mitochondrial (oxidative phosphorylation) and non-mitochondrial (glycolysis) …

Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7-Deazahypoxanthine C7/C8 Ring Systems

AE van der Westhuyzen, N Ashraf… - Journal of Medicinal …, 2024 - ACS Publications
To improve their aqueous solubility characteristics, water-solubilizing groups were added to
some antiproliferative, rigidin-inspired 7-deazahypoxanthine frameworks after molecular …

Enhancing Precision in Photodynamic Therapy: Innovations in Light-Driven and Bioorthogonal Activation

NS Kuzmina, EA Fedotova, P Jankovic, GP Gribova… - Pharmaceutics, 2024 - mdpi.com
Over the past few decades, photodynamic therapy (PDT) has evolved as a minimally
invasive treatment modality offering precise control over cancer and various other diseases …