A number of key mutations that affect treatment and prognosis have been identified in
human gliomas. Two major ways to identify these mutations in a tumor sample are direct …

Abstract The human Far Upstream Element (FUSE) Binding Protein 1 (FUBP1) is a
multifunctional DNA-and RNA-binding protein involved in diverse cellular processes. FUBP1 …

Splicing of pre-mRNAs critically contributes to gene regulation and proteome expansion in
eukaryotes, but our understanding of the recognition and pairing of splice sites during …

RG-7916 is a first-in-class drug candidate for the treatment of spinal muscular atrophy (SMA)
that functions by modulating pre-mRNA splicing of the SMN2 gene, resulting in a 2.5-fold …

Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in
eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it …

RNA splicing is an essential step in producing mature messenger RNA (mRNA) and other
RNA species. Harnessing RNA splicing modifiers as a new pharmacological modality is …

Abstract p53-mediated cell cycle arrest during DNA damage is dependent on the induction
of p21 protein, encoded by the CDKN1A gene. p21 inhibits cyclin-dependent kinases …

Cancer is characterized by alterations that cause the over-proliferation of cells and
hyperactivation of signaling pathways. Alterations of signaling molecules dysregulate …

Endogenous retroviruses (ERV s) are transcriptionally active in cleavage stage embryos, yet
their functions are unknown. ERV sequences are present in the majority of long intergenic …

Transcription factors of the far‐upstream element‐binding protein (FBP) family represent
cellular pathway hubs, and their overexpression in liver cancer (hepatocellular carcinoma …