The rise of multidrug-resistant bacterial infections is a cause of global concern. There is an
urgent need to both revitalize antibacterial agents that are ineffective due to resistance while …

Carbohydrate chemistry is an essential component of the glycosciences and is fundamental
to their progress. This Perspective takes the position that carbohydrate chemistry, or …

Complementing our earlier syntheses of the gentamicins B1, C1a, C2b, and X2, we describe
the synthesis of gentamicins C1, C2, and C2a characterized by methyl substitution at the 6 …

GTPases are regulators of cell signaling acting as molecular switches. The translational
GTPase EF-G stands out, as it uses GTP hydrolysis to generate force and promote the …

A series of new N-1-(β-d-ribofuranosyl) benzimidazole derivatives has been designed using
in silico methods and synthesized as probable antimicrobial agents. Further, the compounds …

Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate
reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and …

The computer added design, synthesis, antibacterial and antifungal activities of a series of
quinoline derivatives and some isosteres are reported. In silico studies using autodock …

For more than three decades, RNA has been known to be a relevant and attractive
macromolecule to target but figuring out which RNA should be targeted and how remains …

Abstract Modification at the 5''‐position of 4, 5‐disubstituted aminoglycoside antibiotics
(AGAs) to circumvent inactivation by aminoglycoside modifying enzymes (AMEs) is well …

Apramycin is a clinically promising aminoglycoside antibiotic (AGA). To date, mechanisms
underlying the biosynthesis and self‐resistance of apramycin remain largely unknown. Here …