Glutamate as a neurotransmitter in the healthy brain
Y Zhou, NC Danbolt - Journal of neural transmission, 2014 - Springer
Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …
Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1,
are coordinately elevated in a wide spectrum of primary human cancers, suggesting that …
are coordinately elevated in a wide spectrum of primary human cancers, suggesting that …
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
B Mackenzie, JD Erickson - Pflügers Archiv, 2004 - Springer
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family
resemble the classically-described System A and System N transport activities in terms of …
resemble the classically-described System A and System N transport activities in terms of …
[HTML][HTML] The glutamate–glutamine (GABA) cycle: importance of late postnatal development and potential reciprocal interactions between biosynthesis and degradation
L Hertz - Frontiers in endocrinology, 2013 - frontiersin.org
The gold standard for studies of glutamate–glutamine (GABA) cycling and its connections to
brain biosynthesis from glucose of glutamate and GABA and their subsequent metabolism …
brain biosynthesis from glucose of glutamate and GABA and their subsequent metabolism …
Glial glutamine homeostasis in health and disease
JV Andersen, A Schousboe - Neurochemical Research, 2023 - Springer
Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …
linked to glutamine, including ammonia homeostasis, energy metabolism and …
The SLC38 family of sodium–amino acid co-transporters
S Bröer - Pflügers Archiv-European Journal of Physiology, 2014 - Springer
Transporters of the SLC38 family are found in all cell types of the body. They mediate Na+-
dependent net uptake and efflux of small neutral amino acids. As a result they are …
dependent net uptake and efflux of small neutral amino acids. As a result they are …
Roles of glutamine in neurotransmission
J Albrecht, M Sidoryk-Węgrzynowicz, M Zielińska… - Neuron glia …, 2010 - cambridge.org
Glutamine (Gln) is found abundantly in the central nervous system (CNS) where it
participates in a variety of metabolic pathways. Its major role in the brain is that of a …
participates in a variety of metabolic pathways. Its major role in the brain is that of a …
A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release
Biochemical studies suggest that excitatory neurons are metabolically coupled with
astrocytes to generate glutamate for release. However, the extent to which glutamatergic …
astrocytes to generate glutamate for release. However, the extent to which glutamatergic …
Role of retinal glial cells in neurotransmitter uptake and metabolism
A Bringmann, T Pannicke, B Biedermann… - Neurochemistry …, 2009 - Elsevier
In addition to photoreceptors and neurons, glial cells (in particular Müller cells) contribute to
the removal and metabolization of neurotransmitters in the neural retina. This review …
the removal and metabolization of neurotransmitters in the neural retina. This review …
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects
HB Schiöth, S Roshanbin, MGA Hägglund… - Molecular aspects of …, 2013 - Elsevier
About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary
substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC …
substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC …