The ubiquitin (Ub)-proteasome system (UPS) plays a pivotal role in maintaining protein
homeostasis and function to modulate various cellular processes including skeletal cell …

Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global
aging population has led to a surge in OA cases, thereby imposing a significant …

Osteoclasts ubiquitously participate in bone homeostasis, and their aberration leads to bone
diseases, such as osteoporosis. Current clinical strategies by biochemical signaling …

Deubiquitinases (DUBs) are essential for bone remodeling by regulating the differentiation
of osteoblast and osteoclast. USP17 encodes for a deubiquitinating enzyme, specifically …

Osteoporosis is an ageing‐related disease, that has become a major public health problem
and its pathogenesis has not yet been fully elucidated. Substantial evidence suggests a …

Breast cancer is the most common female malignancy worldwide. Ubiquitin-specific
peptidase 53 (USP53) has been shown to exert cancer-suppressing functions in several …

Osteoporosis is a common skeletal disease that results in an increased risk of fractures.
However, there is no definitive cure, warranting the development of potential therapeutic …

Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss | Current Osteoporosis
Reports Skip to main content SpringerLink Account Menu Find a journal Publish with us Track …

Bone is a living, intricate, and dynamic tissue providing locomotion and protection of the
body. It also performs hematopoiesis and mineral homeostasis. Osteosarcoma (OS), Ewing …

Obesity is a widespread nutritional disorder, leading to a strong predisposition toward
adverse health consequences. Activating transcription factor 3 (ATF3), a stress-induced …