The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug
development in cognitive and neuro-degenerative disorders, are allosteric proteins with …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

Allosteric interactions play vital roles in metabolic processes and signal transduction and,
more recently, have become the focus of numerous pharmacological studies because of the …

Allosteric modulation refers to the concept that proteins could exist in multiple
conformational states and that binding of allosteric ligands alters the energy barriers or …

Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate
in diverse functions: reward, learning and memory, mood, sensory processing, pain, and …

Positive allosteric modulators of α7 nicotinic acetylcholine receptors (nAChRs) have
attracted considerable interest as potential tools for the treatment of neurological and …