Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Gemcitabine is the first-line treatment for pancreatic adenocarcinoma, but is increasingly
used to treat breast, bladder, and non-small cell lung cancers. Despite such broad use …

To study the regulatory effect of lnc RNA HOTAIR/miR‐20a‐5p/HMGA 2 axis on breast
cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The microarray data of …

The rates of obesity and diabetes are increasing worldwide, whereas the age of onset for
both obesity and diabetes are decreasing steadily. Obesity and diabetes are associated with …

Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

Abstract The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily
recent member of the immunoglobulin super-family, encoded in the Class III region of the …

Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several
properties, including a marked reduction in their self-renewal activity. We now show that the …

Despite the high prevalence and poor outcome of patients with metastatic lung cancer the
mechanisms of tumour progression and metastasis remain largely uncharacterized. Here we …

Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin
effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with …

Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell (HSC)
disease that presents with haemolytic anaemia, thrombosis and smooth muscle dystonias …