Cuproptosis was a copper-dependent and unique kind of cell death that was separate from
existing other forms of cell death. The last decade has witnessed a considerable increase in …

As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

The last 25 years have witnessed tremendous progress in identifying and characterizing
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …

Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its
correct distribution and avoid uncontrolled redox reactions. Several studies address copper …

Vascular endothelial growth factor receptor type 2 (VEGFR2, also known as KDR and FLK1)
signalling in endothelial cells (ECs) is essential for developmental and reparative …

In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Metals are vital for life as they are necessary for essential biological processes. Traditionally,
metals are categorized as either dynamic signals or static cofactors. Redox-inactive metals …