Drugs in development for malaria

EA Ashley, AP Phyo - Drugs, 2018 - Springer
The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Prevention of malaria in pregnancy

M Desai, J Hill, S Fernandes, P Walker… - The Lancet infectious …, 2018 - thelancet.com
Malaria remains one of the most preventable causes of adverse birth outcomes. Intermittent
preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine is used to prevent …

Advances and roadblocks in the treatment of malaria

B Hanboonkunupakarn, NJ White - British journal of clinical …, 2022 - Wiley Online Library
The deployment of artesunate for severe malaria and the artemisinin combination therapies
(ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics …

Malaria chemoprevention in the postdischarge management of severe anemia

TK Kwambai, A Dhabangi, R Idro… - … England Journal of …, 2020 - Mass Medical Soc
Background Children who have been hospitalized with severe anemia in areas of Africa in
which malaria is endemic have a high risk of readmission and death within 6 months after …

Novel approaches to control malaria in forested areas of Southeast Asia

L von Seidlein, TJ Peto, R Tripura, C Pell, S Yeung… - Trends in …, 2019 - cell.com
The emergence and spread of drug resistance in the Greater Mekong Subregion (GMS)
have added urgency to accelerate malaria elimination while reducing the treatment options …

Antimalarial drugs for treating and preventing malaria in pregnant and lactating women

M Saito, ME Gilder, R McGready… - Expert Opinion on Drug …, 2018 - Taylor & Francis
Introduction: Malaria in pregnancy and postpartum cause maternal mortality and adverse
fetal outcomes. Efficacious and safe antimalarials are needed to treat and prevent such …

Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children

P Chotsiri, I Zongo, P Milligan, YD Compaore… - Nature …, 2019 - nature.com
Young children are the population most severely affected by Plasmodium falciparum
malaria. Seasonal malaria chemoprevention (SMC) with amodiaquine and sulfadoxine …

[HTML][HTML] School-aged children based seasonal malaria chemoprevention using artesunate-amodiaquine in Mali

MA Thera, AK Kone, B Tangara, E Diarra… - Parasite epidemiology …, 2018 - Elsevier
Introduction Malaria is still a public health problem in Africa. Seasonal Malaria
Chemoprevention (SMC) is an efficient control strategy recommended by WHO that targets …

Intermittent preventive treatment for malaria in pregnancy: optimization of target concentrations of dihydroartemisinin-piperaquine

RM Savic, P Jagannathan, R Kajubi… - Clinical Infectious …, 2018 - academic.oup.com
Abstract Background Dihydroartemisinin-piperaquine (DHA-PQ) is highly efficacious as
intermittent preventive therapy for malaria during pregnancy (IPTp). Determining …

Malaria PK/PD and the role pharmacometrics can play in the global health arena: malaria treatment regimens for vulnerable populations

E Hughes, E Wallender, A Mohamed Ali… - Clinical …, 2021 - Wiley Online Library
Malaria is an infectious disease which disproportionately effects children and pregnant
women. These vulnerable populations are often excluded from clinical trials resulting in one …