Ubiquitination, a post-translational modification, regulates a vast array of fundamental
biological processes with dysregulation of the dedicated enzymes giving rise to pathologies …

Ubiquitination regulates almost every life process of eukaryotes. The study of the ubiquitin
(Ub) coupling or decoupling process and the interaction study of Ub–Ub binding protein …

Ubiquitin (Ub)‐like protein ISG15 (interferon‐stimulated gene 15) regulates innate immunity
and links with the evasion of host response by viruses such as SARS‐CoV‐2. Dissecting …

Abstract Triazole‐based deubiquitylase (DUB)‐resistant ubiquitin (Ub) probes have recently
emerged as effective tools for the discovery of Ub chain‐specific interactors in proteomic …

Highlights•(Semi)-synthetic ubiquitin–conjugate synthesis adds useful tools to study
ubiquitin signals.•Solution NMR studies show the structural variability of semi-synthetic …

N-Boc-N-(2-(tritylthio) ethoxy) glycine has been developed as a building block for peptide
ubiquitination, which is fully compatible with solid-phase Fmoc chemistry and common …

Post-translational protein modification by ubiquitin (Ub) and Ub-like modifiers is orchestrated
by the sequential action of Ub-activating,-conjugating, and-ligating enzymes to regulate a …

Site-selective conjugation chemistry has proven effective to synthesize homogenously
ubiquitinated histones. Recently, a powerful strategy using 2-((2-chloroethyl) amino) ethane …

Ubiquitin (Ub) chain isopeptide bond mimics are useful molecules for biochemical and
biophysical studies. Herein, we report the semi-synthesis of the disulfide-linked K11/K48 …

Ubiquitination and SUMOylation of protein are crucial for various biological responses. The
recent unraveling of cross-talk between SUMO and ubiquitin (Ub) has shown the pressing …