Enzymatic noncovalent synthesis

H He, W Tan, J Guo, M Yi, AN Shy, B Xu - Chemical reviews, 2020 - ACS Publications
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

C Jiang, H Huang, X Kang, L Yang, Z Xi… - Chemical Society …, 2021 - pubs.rsc.org
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

Controllable protein phase separation and modular recruitment to form responsive membraneless organelles

BS Schuster, EH Reed, R Parthasarathy… - Nature …, 2018 - nature.com
Many intrinsically disordered proteins self-assemble into liquid droplets that function as
membraneless organelles. Because of their biological importance and ability to colocalize …

Enzyme‐instructed self‐assembly (EISA) and hydrogelation of peptides

J Gao, J Zhan, Z Yang - Advanced Materials, 2020 - Wiley Online Library
Self‐assembly is a powerful tool for constructing supramolecular materials for many
applications, ranging from energy harvesting to biomedicine. Among the methods to prepare …

Fmoc-diphenylalanine gelating nanoarchitectonics: A simplistic peptide self-assembly to meet complex applications

Y Wang, Q Geng, Y Zhang, L Adler-Abramovich… - Journal of Colloid and …, 2023 - Elsevier
fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF), has been has been extensively
explored due to its ultrafast self-assembly kinetics, inherent biocompatibility, tunable …

Enzyme‐Instructed Self‐Assembly Enabled Monomer–Excimer Transition to Construct Higher Ordered Luminescent Supramolecular Assembly for Activity‐based …

Y Zhong, J Zhan, G Xu, Y Chen, Q Qin… - Angewandte Chemie …, 2021 - Wiley Online Library
It is challenging to construct high‐performing excimer‐based luminescent analytic tools at
low molecular concentrations. We report that enzyme‐instructed self‐assembly (EISA) …

Bioinspired supramolecular lubricating hydrogel induced by shear force

X Zhang, J Wang, H Jin, S Wang… - Journal of the American …, 2018 - ACS Publications
Bioinspired lubricating materials are great challenge toward artificial joints. In this
contribution, we synthesize a bioinspired hydrogel by combining a thixotropic …

Enhanced cellular uptake and nuclear accumulation of drug-peptide nanomedicines prepared by enzyme-instructed self-assembly

C Liang, X Yan, R Zhang, T Xu, D Zheng, Z Tan… - Journal of Controlled …, 2020 - Elsevier
Subcellular delivery of nanomedicines has emerged as a promising approach to enhance
the therapeutic efficacy of anticancer drugs. Nuclear accumulation of anticancer drugs are …

Intracellular self‐assembly of peptide conjugates for tumor imaging and therapy

Y Deng, W Zhan, G Liang - Advanced Healthcare Materials, 2021 - Wiley Online Library
Intracellular self‐assembly (ISA) is a versatile and powerful strategy for in situ constructing
sophisticated and functional supramolecular nanostructures, which has been widely applied …

Supramolecular nanofibers with superior bioactivity to insulin-like growth factor-I

Y Shang, D Zhi, G Feng, Z Wang, D Mao, S Guo… - Nano Letters, 2019 - ACS Publications
Bioactive peptides derived from proteins generally need to be folded into secondary
structures to activate downstream signaling pathways. However, synthetic peptides typically …