EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review
J Yang, R Xu, C Wang, J Qiu, B Ren… - Cancer …, 2021 - Wiley Online Library
Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most
pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to …
pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to …
Protein acylation: mechanisms, biological functions and therapeutic targets
S Shang, J Liu, F Hua - Signal Transduction and Targeted Therapy, 2022 - nature.com
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …
TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …
The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease
The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …
range of important cellular functions including protein biosynthesis, folding, and trafficking …
[PDF][PDF] Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol‐induced liver damage, steatosis, and inflammation in mice
A Ambade, P Lowe, K Kodys, D Catalano… - …, 2019 - Wiley Online Library
Kupffer cell and macrophage (MØ) activation contributes to steatosis, inflammation, and
fibrosis in alcoholic liver disease (ALD). We found increased frequency of MØ, T cells, and …
fibrosis in alcoholic liver disease (ALD). We found increased frequency of MØ, T cells, and …
An overview of porous silica immobilized amines for direct air CO 2 capture
An increased level of CO2 in the atmosphere is identified as a threat to life on planet earth.
Since hydrogenation of CO2 back to fuel is identified as a major solution for both decreasing …
Since hydrogenation of CO2 back to fuel is identified as a major solution for both decreasing …
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation
Impaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis.
However, how aberrant autophagy promotes fibrosis is far from understood. Here, we aimed …
However, how aberrant autophagy promotes fibrosis is far from understood. Here, we aimed …