Viral recognition and the antiviral interferon response

L Dalskov, HH Gad, R Hartmann - The EMBO Journal, 2023 - embopress.org
Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response
to viral infections. In response to viral stimuli, cells produce and release interferons, which …

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

S Yum, M Li, Y Fang, ZJ Chen - Proceedings of the …, 2021 - National Acad Sciences
The induction of type I interferons through the transcription factor interferon regulatory factor
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …

Host genetic susceptibility to viral infections: the role of type I interferon induction

M Bourdon, C Manet, X Montagutelli - Genes & Immunity, 2020 - nature.com
The innate immune response is the major front line of defense against viral infections. It
involves hundreds of genes with antiviral properties which expression is induced by type I …

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

TM Campbell, Z Liu, Q Zhang… - Journal of Experimental …, 2022 - rupress.org
Autosomal recessive IRF7 deficiency was previously reported in three patients with single
critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and …

Interferon-β plays a detrimental role in experimental traumatic brain injury by enhancing neuroinflammation that drives chronic neurodegeneration

JP Barrett, RJ Henry, KA Shirey, SJ Doran… - Journal of …, 2020 - Soc Neuroscience
DNA damage and type I interferons (IFNs) contribute to inflammatory responses after
traumatic brain injury (TBI). TBI-induced activation of microglia and peripherally-derived …

miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis

CM Rosenberger, RL Podyminogin, AH Diercks… - PLoS …, 2017 - journals.plos.org
Antiviral responses must rapidly defend against infection while minimizing inflammatory
damage, but the mechanisms that regulate the magnitude of response within an infected cell …

Innate immune sensing of viruses and its consequences for the central nervous system

H Singh, J Koury, M Kaul - Viruses, 2021 - mdpi.com
Viral infections remain a global public health concern and cause a severe societal and
economic burden. At the organismal level, the innate immune system is essential for the …

[HTML][HTML] Host innate antiviral response to influenza A virus infection: from viral sensing to antagonism and escape

W An, S Lakhina, J Leong, K Rawat, M Husain - Pathogens, 2024 - mdpi.com
Influenza virus possesses an RNA genome of single-stranded, negative-sensed, and
segmented configuration. Influenza virus causes an acute respiratory disease, commonly …

Inflammation and pneumonia: why are some more susceptible than others?

JP Mizgerd - Clinics in chest medicine, 2018 - chestmed.theclinics.com
Pneumonia is a very unusual outcome of very common host-microbe interactions.
Pneumonias are caused by a large variety of ubiquitous and unavoidable microbes, such as …

Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses

M Zhao, Y Zhang, X Yang, J Jin, Z Shen, X Feng… - PLoS …, 2021 - journals.plos.org
Neddylation, an important type of post-translational modification, has been implicated in
innate and adapted immunity. But the role of neddylation in innate immune response against …