Endogenous pancreatic β cell regeneration is a potential strategy for β cell expansion or
neogenesis to treat diabetes. Regeneration can occur through stimulation of existing β cell …

The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …

Abstract Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells.
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …

Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the
removal of impaired tissue and activation of a program leading to organ regeneration pose …

The regulation of islet cell biology is critical for glucose homeostasis. N 6-methyladenosine
(m6A) is the most abundant internal messenger RNA (mRNA) modification in mammals …

Restoring functional β-cell mass is an important therapeutic goal for both type 1 and type 2
diabetes. While proliferation of existing β-cells is the primary means of β-cell replacement in …

Although compensatory islet hyperplasia in response to insulin resistance is a recognized
feature in diabetes, the factor (s) that promote β cell proliferation have been elusive. We …

MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic
form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene …

Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes.
Here, we report the pathways utilized by β cells to robustly replicate in response to acute …

Although diabetes results in part from a deficiency of normal pancreatic beta cells, inducing
human beta cells to regenerate is difficult. Reasoning that insulinomas hold the “genomic …