Background Anthrax is endemic to many countries, including the United States. The
causative agent, Bacillus anthracis, poses a global bioterrorism threat. Without effective …

SUMMARY The World Health Organisation's 2022 AWaRe Book provides guidance for the
use of 39 antibiotics to treat 35 infections in primary healthcare and hospital facilities. We …

Introduction: Doxycycline is an antibiotic with known gastrointestinal (GI) adverse effects.
Esophagitis is the most pronounced among these effects, and might be associated with a …

Nonlinear protein binding is traditionally thought of as an increasing fraction unbound with
increasing total drug concentration. In the past several years, research into the protein …

COMPASS is a novel tool for predicting the in vivo similarity of immediate-release oral
dosage forms. It bridges the gap between straightforward but purely mathematical f2 factor …

Aims Doxycycline (DFD‐09) oral capsules 40 mg are approved for the treatment of
inflammatory lesions of rosacea. Unlike the food‐induced lowering of doxycycline's peak …

Doxycycline is a tetracycline-class antimicrobial labeled by the US Food and Drug
Administration for children> 8 years of age for many common childhood infections …

Racemic praziquantel (PZQ) is the standard treatment for schistosomiasis and liver fluke
infections (opisthorchiasis and clonorchiasis). The development of an optimal pediatric …

Purpose An influential covariate for pharmacokinetics is (body) size. Recently, the method of
estimation of normal fat mass (NFM) has been advocated. Here, the relative contribution of …

Doxycycline (DOX) is the antibiotic of choice for the treatment of canine monocytic
ehrlichiosis (CME), one of the main infectious diseases affecting dogs. Despite the …