Polyelectrolyte-multivalent molecule complexes: physicochemical properties and applications

SE Herrera, ML Agazzi, E Apuzzo, ML Cortez… - Soft Matter, 2023 - pubs.rsc.org
The complexation of polyelectrolytes with other oppositely charged structures gives rise to a
great variety of functional materials with potential applications in a wide spectrum of …

Determinants of viscoelasticity and flow activation energy in biomolecular condensates

I Alshareedah, A Singh, S Yang, V Ramachandran… - Science …, 2024 - science.org
The form and function of biomolecular condensates are intimately linked to their material
properties. Here, we integrate microrheology with molecular simulations to dissect the …

Endoproteolysis of oligopeptide-based coacervates for enzymatic modeling

Z Jin, C Ling, W Yim, YC Chang, T He, K Li, J Zhou… - ACS …, 2023 - ACS Publications
Better insights into the fate of membraneless organelles could strengthen the understanding
of the transition from prebiotic components to multicellular organisms. Compartmentalized …

A mini-review on bio-inspired polymer self-assembly: single-component and interactive polymer systems

X Meng - Emerging Topics in Life Sciences, 2022 - portlandpress.com
Biology demonstrates meticulous ways to control biomaterials self-assemble into ordered
and disordered structures to carry out necessary bioprocesses. Empowering the synthetic …

Polysaccharide-based polyampholyte complex formation: Investigating the role of intra-chain interactions

E Avazverdi, H Mirzadeh, M Ehsani… - Carbohydrate …, 2023 - Elsevier
The difference in inter-chain and intra-chain electrostatic attraction was investigated in
polyelectrolyte and polyampholyte electrostatic complex formation. Three polymers with …

Coacervate Formation in Dilute Aqueous Solutions of Inorganic Molecular Clusters with Simple Divalent Countercations

K Xiao, Y Yang, X Xu, JES Szymanowski… - Inorganic …, 2024 - ACS Publications
We report a complex coacervate formed by a 2.5 nm-diameter, rigid uranyl peroxide
molecular cluster (Li68K12 (OH) 20)[UO2 (O2) OH] 60, U6060–) and SrCl2 salt in dilute …

Sequestration of Small Ions and Weak Acids and Bases by a Polyelectrolyte Complex Studied by Simulation and Experiment

R Stano, JJ van Lente, S Lindhoud… - Macromolecules, 2024 - ACS Publications
Mixing of oppositely charged polyelectrolytes can result in phase separation into a polymer-
poor supernatant and a polymer-rich polyelectrolyte complex (PEC). We present a new …

Predictive design of multimonomeric polyelectrolytes enables lung-specific gene delivery

JM Ting, JD Fisher, T Conyers, S Patil, CG Robohn… - Polymer …, 2024 - pubs.rsc.org
We present a class of programmable polymer nanoparticles capable of intravenous pDNA
delivery with∼ 350 000-fold enhancement of specificity to the lung by qPCR in mice …

Bulk Biopolyelectrolyte Complexes from Homopolypeptides: Solid “Salt Bridges”

ZA Digby, Y Chen, K Akkaoui, JB Schlenoff - Biomacromolecules, 2023 - ACS Publications
Salt bridges, pairings between oppositely charged amino acids, are dispersed throughout
proteins to assist folding and interactions. Biopolyelectrolyte complexes (BioPECs) were …

Viscoelasticity of globular protein-based biomolecular condensates

RS Fisher, AC Obermeyer - bioRxiv, 2023 - biorxiv.org
The phase separation of biomolecules into biomolecular condensates has emerged as a
ubiquitous cellular process. Understanding how intrinsically disordered protein sequence …