▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …

From Levinthalto pathways to funnels Page 1 TS 9 1997 Nature Publishing Group http://www.nature.com/nsmb
perspective From Levinthalto pathways to funnels Ken A. Dill and Hue Sun Chan A new …

Proteins have dynamic structures that undergo chain motions on time scales spanning from
picoseconds to seconds. Resolving the resultant conformational heterogeneity is essential …

This paper surveys the emerging role of statistical mechanics and polymer theory in protein
folding. In the polymer perspective, the folding code is more a solvation code than a code of …

The lipocalin family became established shortly after the structural similarity was noted
between plasma retinol binding protein and the bovine milk protein, β-lactoglobulin. During …

Among various alcohols, those substituted with fluorine, such as 2, 2, 2-trifluoroethanol
(TFE) or 3, 3, 3, 3 ', 3 ', 3 '-hexafluoro-2-propanol (HFIP), have a marked potential to induce …

Publisher Summary This chapter deals with the structure of the molten globules of various
globular proteins revealed by the recent experimental studies. Recent advances in …

The aggregation of α‐helix‐rich proteins into β‐sheet‐rich amyloid fibrils is associated with
fatal diseases, such as Alzheimer's disease and prion disease. During an aggregation …

We use two simple models and the energy landscape perspective to study protein folding
kinetics. A major challenge has been to use the landscape perspective to interpret …

The folding reactions of some small proteins show clear evidence of a hierarchic process,
whereas others, lacking detectable intermediates, do not. Evidence from folding …