Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

G Copp, KP Robb, S Viswanathan - Cellular & Molecular Immunology, 2023 - nature.com
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …

Effect of mesenchymal stromal cells transplantation on the outcomes of patients with knee osteoarthritis: A systematic review and meta‐analysis

R Xie, S Gong, J Song, P Wu… - Journal of Orthopaedic …, 2024 - Wiley Online Library
Cell therapy has been explored as a new regenerative treatment for osteoarthritis in the field
of regenerative medicine. However, the efficacy of stem cell transplantation from different …

Within or without you? A perspective comparing in situ and ex situ tissue engineering strategies for articular cartilage repair

CD O'Connell, S Duchi, C Onofrillo… - Advanced …, 2022 - Wiley Online Library
Human articular cartilage has a poor ability to self‐repair, meaning small injuries often lead
to osteoarthritis, a painful and debilitating condition which is a major contributor to the global …

Pro-inflammatory cytokine priming and purification method modulate the impact of exosomes derived from equine bone marrow mesenchymal stromal cells on equine …

M Jammes, F Cassé, E Velot, A Bianchi… - International journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a widespread osteoarticular pathology characterized by progressive
hyaline cartilage degradation, exposing horses to impaired well-being, premature career …

Housekeeping Gene Stability in Adipose Mesenchymal Stromal Cells Cultivated in Serum/Xeno-Free Media for Osteoarthritis

E Ragni, S Piccolo, P De Luca, M Taiana, G Grieco… - Cells, 2024 - mdpi.com
Among the available therapeutics for the conservative treatment of osteoarthritis (OA),
mesenchymal stromal cells (MSCs)-based products appear to be the most promising …

Strategy insight: Mechanical properties of biomaterials' influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy

H Ying, C Shen, R Pan, X Li, Y Chen - Frontiers in Pharmacology, 2023 - frontiersin.org
Osteoarthritis (OA) is a kind of degenerative joint disease usually found in older adults and
those who have received meniscal surgery, bringing great suffering to a number of patients …

Secreted factors and extracellular vesicles account for the immunomodulatory and tissue regenerative properties of bone-marrow-derived mesenchymal stromal cells …

E Ragni, C Perucca Orfei, L de Girolamo - Cells, 2022 - mdpi.com
Bone-marrow-derived mesenchymal stromal cells (BMSCs) showed therapeutic potential in
the treatment of musculoskeletal diseases, including osteoarthritis (OA). Their soluble …

Implication of cellular senescence in osteoarthritis: a study on equine synovial fluid mesenchymal stromal cells

G Teti, E Mazzotti, V Gatta, F Chiarini, ML Alfieri… - International journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is described as a chronic degenerative disease characterized by the loss
of articular cartilage. Senescence is a natural cellular response to stressors. Beneficial in …

Human adipose-and amnion-derived mesenchymal stromal cells similarly mitigate osteoarthritis progression in the Dunkin Hartley guinea pig

A Kwapisz, M Bowman, J Walters… - … American Journal of …, 2022 - journals.sagepub.com
Background: Clinical trials are currently underway to investigate the efficacy of intra-articular
administration of mesenchymal stromal cells (MSCs) to mitigate osteoarthritis (OA) …

Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment

H Chu, S Zhang, Z Zhang, H Yue, H Liu, B Li… - NPJ Regenerative …, 2024 - nature.com
Osteoarthritis affects 15% of people over 65 years of age. It is characterized by articular
cartilage degradation and inflammation, leading to joint pain and disability. Osteoarthritis is …