Histamine is a biogenic amine that acts as a neuromodulator within the brain. In the
hypothalamus, histaminergic signaling contributes to the regulation of numerous …

In an attempt to extend recent studies showing that some clinically evaluated histamine H3
receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we …

In search of new dual-acting histamine H3/sigma-1 receptor ligands, we designed a series
of compounds structurally based on highly active in vivo ligands previously studied and …

Alzheimeŕs disease (AD) is the most prominent neurodegenerative disorder with high
medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where …

Many studies involving compounds that enhance histamine release, such as histamine H3
receptor (H3R) antagonists, have shown efficacy in inhibiting weight gain, but none have …

Schizophrenia is a mental disorder with a complex pathomechanism involving many
neurotransmitter systems. Among the currently used antipsychotics, classical drugs acting as …

We previously reported that synthetic oleoyl chalcones had a favorable effect to alleviate
metabolic consequences of obesity in male SD rats. In this work, we prepared and …

GPR18 has been proposed to play a role in the progression of metabolic disease and
obesity. Therefore, the aim of this study was to determine the effects of selective GRP18 …

Background: Numerous studies highlight the critical role that neural histamine plays in
feeding behavior, which is controlled by central histamine H3 and H1 receptors. This is the …

Aims One of the therapeutic approaches in the treatment of obesity is the use of histamine H
3 receptor ligands. Histamine plays a significant role in eating behavior because it causes a …