Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …

The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic
biology, including genetics, development, cell biology, and genomics. A major factor in the …

Background The binding of transcription factors (TF) to genomic targets is critical in the
regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely …

Transcription factors are DNA-binding proteins that have key roles in gene regulation,.
Genome-wide occupancy maps of transcriptional regulators are important for understanding …

Actively dividing cells, including some cancers, rely on aerobic glycolysis rather than
oxidative phosphorylation to generate energy, a phenomenon termed the Warburg effect …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most popular
assay to identify genomic regions, called ChIP-seq peaks, that are bound in vivo by …

Background Deep learning has proven to be a powerful technique for transcription factor
(TF) binding prediction but requires large training datasets. Transfer learning can reduce the …

Housekeeping genes are considered to be regulated by common enhancers across different
tissues. Here we report that most of the commonly expressed mouse or human genes across …

Transcription factors (TFs) orchestrate gene expression programs crucial for brain function,
but we lack detailed information about TF binding in human brain tissue. We generated a …

Early studies in mouse neurodevelopment led to the discovery of the RE1 Silencing
Transcription Factor (REST) and its role as a master repressor of neuronal gene expression …