Multiple roles of vestigial-like family members in tumor development

N Yamaguchi - Frontiers in Oncology, 2020 - frontiersin.org
Vestigial-like family (VGLL) members are mammalian orthologs of vestigial gene in
Drosophila, and they consist of four homologs (VGLL1–4). VGLL members have TDU motifs …

TEAD4 as an Oncogene and a Mitochondrial Modulator

SC Hsu, CY Lin, YY Lin, CC Collins… - Frontiers in Cell and …, 2022 - frontiersin.org
TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein
of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in …

Low RNA stability signifies strong expression regulatability of tumor suppressors

X Gao, Y Yi, J Lv, Y Li, K Arulsamy… - Nucleic acids …, 2023 - academic.oup.com
RNA expression of a gene is determined by not only transcriptional regulation, but also post-
transcriptional regulation of RNA decay. The precise regulation of RNA stability in the cell …

Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR‐942‐5p and releasing DLG2 via Hippo‐YAP signaling

S Li, G Yan, W Liu, C Li, X Wang - Molecular Carcinogenesis, 2020 - Wiley Online Library
This study aimed to investigate the role of circ0106714‐miR‐942‐5p‐discs large homolog 2
(DLG2), a novel interactome, in colorectal cancer (CRC). Circ0106714 was found to be the …

Glioma stem cell‐derived exosomes induce the transformation of astrocytes via the miR‐3065‐5 p/DLG2 signaling axis

H Li, J Zhu, X Liu, L Liu, S Huang, A Wu, Z Xu, X Zhang… - Glia, 2024 - Wiley Online Library
Tumor‐associated astrocytes (TAAs) in the glioblastoma microenvironment play an
important role in tumor development and malignant progression initiated by glioma stem …

LncRNA MNX1-AS1 promotes progression of intrahepatic cholangiocarcinoma through the MNX1/Hippo axis

F Li, Q Chen, H Xue, L Zhang, K Wang, F Shen - Cell Death & Disease, 2020 - nature.com
Long non-coding RNAs (lncRNAs) have extremely complex roles in the progression of
intrahepatic cholangiocarcinoma (ICC) and remain to be elucidated. By cytological and …

Gene therapy for liver cancers: current status from basic to clinics

K Kamimura, T Yokoo, H Abe, S Terai - Cancers, 2019 - mdpi.com
The liver is a key organ for metabolism, protein synthesis, detoxification, and endocrine
function, and among liver diseases, including hepatitis, cirrhosis, malignant tumors, and …

Malate initiates a proton-sensing pathway essential for pH regulation of inflammation

Y Chen, R Shi, Y Xiang, L Fan, H Tang, G He… - … and Targeted Therapy, 2024 - nature.com
Metabolites can double as a signaling modality that initiates physiological adaptations.
Metabolism, a chemical language encoding biological information, has been recognized as …

The transcriptional co-factor IRF2BP2: A new player in tumor development and microenvironment

TP Pastor, BC Peixoto, JPB Viola - Frontiers in Cell and …, 2021 - frontiersin.org
Interferon regulatory factor 2-binding protein 2 (IRF2BP2) encodes a member of the IRF2BP
family of transcriptional regulators, which includes IRF2BP1, IRF2BP2, and IRF2BPL …

Quercetin acts as a novel anti-cancer drug to suppress cancer aggressiveness and cisplatin-resistance in nasopharyngeal carcinoma (NPC) through regulating the …

T Li, Y Li - Immunobiology, 2023 - Elsevier
Background Quercetin has been proven to be effective for cancer treatment, including
nasopharyngeal carcinoma (NPC). Also, Quercetin sensitizes cancer cells to current …