Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Analysis and systematization of accumulated data on carbohydrate structural diversity is a
subject of great interest for structural glycobiology. Despite being a challenging task …

Protein-carbohydrate interactions govern a wide variety of biological processes and play an
essential role in the development of different diseases. Here, we present DIONYSUS, the …

Lectins are non-covalent glycan-binding proteins mediating cellular interactions but their
annotation in newly sequenced organisms is lacking. The limited size of functional domains …

The greatest challenge in drug discovery remains the high rate of attrition across the
different phases of the process, which cost the industry billions of dollars every year. While …

The present work investigates the impact of dietary-carbohydrate chain length on the
binding affinity with Agaricus bisporus lectin (ABL) using sugars of varying chain length …

As the most abundant organic substances in nature, carbohydrates are essential for life.
Understanding how carbohydrates regulate proteins in the physiological and pathological …

Abstract Since 1971, the Protein Data Bank (PDB) has served as the single global archive
for experimentally determined 3D structures of biological macromolecules made freely …

Carbohydrate chains are ubiquitous in the complex molecular processes of life. These
highly diverse chains are recognized by a variety of protein receptors, enabling glycans to …

Minimalistic peptide-based systems that bind sugars in water are challenging to design due
to the weakness of interactions and required cooperative contributions from specific amino …