RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for
treating diverse diseases. However, their potential is commonly hindered by vulnerability to …

Ocular delivery of lipid nanoparticle (LNPs) packaged mRNA can enable efficient gene
delivery and editing. We generated LNP variants through the inclusion of positively charged …

Gastrointestinal tumors remain a significant healthcare burden worldwide, necessitating the
development of innovative therapeutic strategies. mRNA vaccines have emerged as a …

In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …

CRISPR/Cas technology presents a promising approach for treating a wide range of
diseases, including cancer and genetic disorders. Despite its potential, the translation of …

Patients living with inherited skin diseases have benefited from recent advances in DNA
sequencing technologies that provide new or improved diagnostics. However, developing …

In vivo genome editing holds great therapeutic potential for treating monogenic diseases by
enabling precise gene correction or addition. However, improving the efficiency of delivery …

Purpose of review This review aims to evaluate the potential of CRISPR-based gene editing
tools, particularly prime editors (PE), in treating genetic cardiac diseases. It seeks to answer …

The critical challenge of gene therapy lies in delivering gene editing agents. Compared with
DNA, while RNA is less stable and more accessible to degrade, it comes with the benefit of …

In this special collection, a review on delivery strategies for RNA therapies is presented by
Dr. Oh. The review discusses different strategies employed in the design and development …