The pathobiology of human fungal infections
Human fungal infections are a historically neglected area of disease research, yet they
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …
Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities
An important host defence mechanism against pathogens is intracellular killing, which is
achieved through phagocytosis, a cellular process for engulfing and neutralizing …
achieved through phagocytosis, a cellular process for engulfing and neutralizing …
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis
M Valentine, P Rudolph, A Dietschmann, A Tsavou… - MBio, 2024 - Am Soc Microbiol
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal
candidiasis, which is commonly observed in human immunodeficiency virus infected …
candidiasis, which is commonly observed in human immunodeficiency virus infected …
Epithelial responses to fungal pathogens
Epithelial cells orchestrate immune responses against fungal pathogens. This review
highlights advances in integrating epithelial cells in immune responses against inhaled …
highlights advances in integrating epithelial cells in immune responses against inhaled …
Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities
R Silva-Gomes, I Caldeira, R Fernandes… - Journal of Leukocyte …, 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …
individuals worldwide and resulting in more than 3 million deaths annually. Despite …
Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems
The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …
Ferrous sulphate triggers ferroptosis in Candida albicans and cures vulvovaginal candidiasis in a mouse model
H Mo, T Zhang, J Zhang, S Peng, F Xiang, H Li… - Microbiological …, 2024 - Elsevier
Candida albicans is the most leading cause of life-threatening fungal invasive infections,
especially for vulvovaginal candidiasis (VVC). Resistance and tolerance to common …
especially for vulvovaginal candidiasis (VVC). Resistance and tolerance to common …
Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology
KO Cheng, DE Montano, T Zelante… - Oxford Open …, 2024 - academic.oup.com
Protective immunity to opportunistic fungal infections consists of tightly regulated innate and
adaptive immune responses that clear the infection. Immune responses to infections of the …
adaptive immune responses that clear the infection. Immune responses to infections of the …
Candida albicans and Candida glabrata: global priority pathogens
M Katsipoulaki, MHT Stappers… - Microbiology and …, 2024 - Am Soc Microbiol
SUMMARY A significant increase in the incidence of Candida-mediated infections has been
observed in the last decade, mainly due to rising numbers of susceptible individuals …
observed in the last decade, mainly due to rising numbers of susceptible individuals …
Physiological adventures in Candida albicans: farnesol and ubiquinones
KW Nickerson, DJ Gutzmann, CHT Boone… - Microbiology and …, 2024 - Am Soc Microbiol
Farnesol was first identified as a quorum-sensing molecule, which blocked the yeast to
hyphal transition in Candida albicans, 22 years ago. However, its interactions with Candida …
hyphal transition in Candida albicans, 22 years ago. However, its interactions with Candida …