This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Continuously increasing understanding of the molecular triggers responsible for the onset of
diseases, paralleled by an equally dynamic evolution of chemical synthesis and screening …

Atherosclerosis (AS) features include progressive hardening and reduced elasticity of
arteries. AS is the leading cause of morbidity and mortality. An increasing amount of …

Major depressive disorder (MDD) represents approximately 40% of the disability caused by
mental illnesses globally. The poorly understood pathophysiology and limited efficiency of …

Several new therapeutic strategies are now considered for acute myeloid leukemia (AML)
patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation …

Histone deacetylases (HDACs) 2 play important roles in the epigenetic regulation of gene
expression in cells and are emerging therapeutic targets for treating a wide range of …

The rising incidence of dengue virus (DENV) infections in the tropical and sub-tropical
regions of the world emphasizes the need to identify effective therapeutic drugs against the …

Under physiological conditions, reactive nitrogen and oxygen species are produced
continuously. However, excess of these radicals may damage biomolecules like lipids …

TYK2-rearrangements have recently been identified in high-risk acute lymphoblastic
leukemia (HR-ALL) cases and are associated with poor outcome. Current understanding of …

Activating TYK2-rearrangements have recently been identified and implicated in the
leukemogenesis of high-risk acute lymphoblastic leukemia (HR-ALL) cases. Pre-clinical …