Postoperative delirium severity and recovery correlate with electroencephalogram spectral features

CS Guay, MM Kafashan, ER Huels, Y Jiang… - Anesthesia & …, 2023 - journals.lww.com
BACKGROUND: Delirium is an acute syndrome characterized by inattention, disorganized
thinking, and an altered level of consciousness. A reliable biomarker for tracking delirium …

The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia

AK Labonte, MM Kafashan, ER Huels… - British journal of …, 2023 - Elsevier
Background The posterior dominant rhythm (PDR) was the first oscillatory pattern noted in
the EEG. Evoked by wakeful eyelid closure, these oscillations dissipate over seconds during …

Albumin/fibrinogen ratio, an independent risk factor for postoperative delirium after total joint arthroplasty

L Jiang, G Lei - Geriatrics & Gerontology International, 2022 - Wiley Online Library
Aim Postoperative delirium (POD) is a very common and serious complication after total joint
arthroplasty (TJA), which is closely associated with many adverse consequences and a poor …

Perioperative sleep in geriatric cardiac surgical patients: a feasibility study using a wireless wearable device

MM Kafashan, O Hyche, T Nguyen… - BJA: British Journal …, 2021 - pmc.ncbi.nlm.nih.gov
2. Sunderland S, Yarnold CH, Head SJ, et al. Regional versus general anesthesia and the
incidence of unplanned health care resource utilization for postoperative pain after wrist …

Targeting slow wave sleep deficiency in late-life depression: a case series with propofol

RL Rios, MM Kafashan, O Hyche, E Lenard… - The American Journal of …, 2023 - Elsevier
Slow wave sleep (SWS), characterized by large electroencephalographic oscillations,
facilitates crucial physiologic processes that maintain synaptic plasticity and overall brain …

A personalized semi-automatic sleep spindle detection (PSASD) framework

MM Kafashan, G Gupte, P Kang, O Hyche… - Journal of Neuroscience …, 2024 - Elsevier
Background Sleep spindles are distinct electroencephalogram (EEG) patterns of brain
activity that have been posited to play a critical role in development, learning, and …

Propofol enhancement of slow wave sleep to target the nexus of geriatric depression and cognitive dysfunction: protocol for a phase I open label trial

RL Rios, M Green, SK Smith, MM Kafashan… - BMJ open, 2024 - bmjopen.bmj.com
Introduction Late-life treatment-resistant depression (LL-TRD) is common and increases risk
for accelerated ageing and cognitive decline. Impaired sleep is common in LL-TRD and is a …

Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol

S Subramanian, AK Labonte, T Nguyen… - Frontiers in …, 2022 - frontiersin.org
Introduction Electroconvulsive therapy (ECT) is an effective intervention for patients with
major depressive disorder (MDD). Despite longstanding use, the underlying mechanisms of …

Quantitative electroencephalography predicts postoperative delirium in cardiac surgical patients after cardiopulmonary bypass: a prospective observational study

Y Xue, W Liu, L Su, H He, H Chen, Y Long - Frontiers in Medicine, 2023 - frontiersin.org
Objective Despite its frequency and associated negative effect, delirium remains poorly
recognized in postoperative patients after ICU admission, especially among those who have …

[HTML][HTML] Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adults

SK Smith, MM Kafashan, RL Rios, EN Brown… - BJA open, 2024 - Elsevier
Background The alpha-2 adrenergic agonist dexmedetomidine induces EEG patterns
resembling those of non-rapid eye movement (NREM) sleep. Fulfilment of slow wave sleep …