Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

A myriad of complex processes marry to drive pain perception in health and chronicity. A
final step in proceedings involves the activation of top-down modulatory pathways that can …

Neuropathic pain is a major, inadequately treated challenge for people with spinal cord
injury (SCI). While SCI pain mechanisms are often assumed to be in the CNS, rodent studies …

Extrasynaptic α5‐subunit containing GABAA (α5‐GABAA) receptors participate in chronic
pain. Previously, we reported a sex difference in the action of α5‐GABAA receptors in …

To promote bone repair, it is desirable to develop three-dimensional multifunctional fiber
scaffolds. The densely stacked and tightly arranged conventional two-dimensional …

Epigenetics deals with alterations to the gene expression that occur without change in the
nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the …

Neuropathic pain (NP) is a common symptom in many diseases of the somatosensory
nervous system, which severely affects the patient's quality of life. Epigenetics are heritable …

Objective Multiple factors are involved in the physiology and variability of postsurgical pain,
a great part of which can be explained by genetic and environmental factors and their …

Based on deep RNA sequencing of distal segments of lesioned sciatic nerves, a huge
number of differentially expression genes (DEGs) were thus obtained and functionally …

Pain is one of the most frequent non-motor symptoms of Parkinson's disease (PD).
Neuropathic pain is highly prevalent in PD and negatively affects the quality of life of patients …