Engineered nucleic acids encoding a modified erythropoietin and their expression

JP Schrum, NB Afeyan, GJ Sieczkiewicz… - US Patent …, 2014 - Google Patents
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Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
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Method and apparatus for a multi-use body fluid sampling device with analyte sensing

D Boecker, DM Freeman - US Patent 7,198,606, 2007 - Google Patents
(60) Provisional application No. 60/428,084, filed on Nov. 20, 2002, provisional application
No. 60/424,429,(57) ABSTRACT filed on Nov. 6, 2002, provisional application No …

Engineered nucleic acids and methods of use thereof

JP Schrum, S Bancel, NB Afeyan - US Patent 8,822,663, 2014 - Google Patents
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …

Modified polynucleotides for the production of biologics and proteins associated with human disease

S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
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Modified polynucleotides for the production of secreted proteins

T Chakraborty, A De Fougerolles - US Patent 9,192,651, 2015 - Google Patents
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Pharmaceutical composition containing a stabilised mRNA optimised for translation in its coding regions

F Von Der Mülbe, I Hoerr, S Pascolo - US Patent 10,188,748, 2019 - Google Patents
The present invention relates to a pharmaceutical composi tion comprising a modified
mRNA that is stabilized by sequence modifications and optimized for translation. The …

Engineered nucleic acids and methods of use thereof

S Bancel, JP Schrum, A Aristarkhov - US Patent 9,464,124, 2016 - Google Patents
A61K48/0075—Medicinal preparations containing genetic material which is inserted into
cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of …

In vivo production of proteins

S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
2013-03-19 Assigned to modeRNA Therapeutics reassignment modeRNA Therapeutics
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Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins

T Chakraborty, A De Fougerolles - US Patent 9,303,079, 2016 - Google Patents
2013-03-19 Assigned to modeRNA Therapeutics reassignment modeRNA Therapeutics
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …