Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a “central hub” in schizophrenia pathophysiology?
P Steullet, JH Cabungcal, A Monin, D Dwir… - Schizophrenia …, 2016 - Elsevier
Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons
and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to …
and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to …
Neurophysiology and regulation of the balance between excitation and inhibition in neocortical circuits
Brain function relies on the ability of neural networks to maintain stable levels of activity,
while experiences sculpt them. In the neocortex, the balance between activity and stability …
while experiences sculpt them. In the neocortex, the balance between activity and stability …
Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder
LM Rimol, CB Hartberg, R Nesvåg… - Biological …, 2010 - Elsevier
BACKGROUND: Schizophrenia and bipolar disorder are severe psychiatric diseases with
overlapping symptomatology. Widespread brain morphologic abnormalities, including …
overlapping symptomatology. Widespread brain morphologic abnormalities, including …
The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia
KY Tseng, RA Chambers, BK Lipska - Behavioural brain research, 2009 - Elsevier
Traditionally, animal models of schizophrenia were predominantly pharmacological
constructs focused on phenomena linked to dopamine and glutamate neurotransmitter …
constructs focused on phenomena linked to dopamine and glutamate neurotransmitter …
Long-lasting rescue of network and cognitive dysfunction in a genetic schizophrenia model
Although sensitizing processes occur earlier, schizophrenia is diagnosed in young
adulthood, which suggests that it might involve a pathological transition during late brain …
adulthood, which suggests that it might involve a pathological transition during late brain …
Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia
The lack of efficacy for antipsychotics with respect to negative symptoms and cognitive
deficits is a significant obstacle for the treatment of schizophrenia. Developing new drugs to …
deficits is a significant obstacle for the treatment of schizophrenia. Developing new drugs to …
Schizophrenia as a disorder of disconnectivity
Schizophrenia is considered as a neurodevelopmental disorder with genetic and
environmental factors playing a role. Animal models show that developmental hippocampal …
environmental factors playing a role. Animal models show that developmental hippocampal …
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits
Adult brain function and behavior are influenced by neuronal network formation during
development. Genetic susceptibility factors for adult psychiatric illnesses, such as …
development. Genetic susceptibility factors for adult psychiatric illnesses, such as …
Evaluation of animal models of neurobehavioral disorders
FJ van der Staay, SS Arndt, RE Nordquist - Behavioral and Brain …, 2009 - Springer
Animal models play a central role in all areas of biomedical research. The process of animal
model building, development and evaluation has rarely been addressed systematically …
model building, development and evaluation has rarely been addressed systematically …
Early social experience is critical for the development of cognitive control and dopamine modulation of prefrontal cortex function
PJJ Baarendse, DS Counotte, P O'donnell… - …, 2013 - nature.com
Social experiences during youth are thought to be critical for proper social and cognitive
development. Conversely, social insults during development can cause long-lasting …
development. Conversely, social insults during development can cause long-lasting …