Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

Neurons are highly polarized cells with a single axon and multiple dendrites derived from
the cell body to form tightly associated pre-and postsynaptic compartments. As the …

Voltage-gated calcium (Ca V) channels are associated with β and α 2 δ auxiliary subunits.
This review will concentrate on the function of the α 2 δ protein family, which has four …

Initially developed to generate new treatments for epilepsy, gabapentin, and pregabalin
(“gabapentinoids”) were engineered to mimic the action of GABA and to modulate GABA …

Abstract α 2 δ proteins are membrane-anchored extracellular glycoproteins which are
abundantly expressed in the brain and the peripheral nervous system. They serve as …

The gabapentinoid drugs gabapentin and pregabalin (Neurontin and Lyrica) are mainstay
treatments for neuropathic pain and preventing focal seizures. Both drugs have similar …

The efficacy of neuropathic pain control remains unsatisfactory. Despite the availability of a
variety of therapies, a significant proportion of patients suffer from poorly controlled pain of …

Voltage-gated calcium channel auxiliary α2δ subunits are important for channel trafficking
and function. Here, we compare the effects of α2δ-1 and an α2δ-like protein called Cachd1 …

Objective—Mutations affecting contractile-related proteins in the ECM (extracellular matrix),
microfibrils, or vascular smooth muscle cells can predispose the aorta to aneurysms. We …

Abstract Neuronal voltage-gated Ca2+ (CaV) channels play a critical role in cellular
excitability, synaptic transmission, excitation–transcription coupling and activation of …