Quinoline-containing antimalarial drugs, such as chloroquine, quinine and mefloquine, are
mainstays of chemotherapy against malaria. The molecular basis of the action of these …

Since the first reports of chloroquine-resistant falciparum malaria in southeast Asia and
South America almost half a century ago, drug-resistant malaria has posed a major problem …

Summary Background The borders of Thailand harbour the world's most multidrug resistant
Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for …

Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

Antimarial drug resistance develops when spontaneously occurring parasite mutants with
reduced susceptibility are selected, and are then transmitted. Drugs for which a single point …

Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical
treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be …

Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …

The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts
to implement artemisinin (ART)–based combination therapies for malaria, including …

Two chloroquine-resistant cloned isolates of Plasmodium falciparum were subjected to
mefloquine selection to test if this resulted in alterations in chloroquine sensitivity and …