The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Toward individualized connectomes of brain morphology
The morphological brain connectome (MBC) delineates the coordinated patterns of local
morphological features (such as cortical thickness) across brain regions. While classically …
morphological features (such as cortical thickness) across brain regions. While classically …
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is an international
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
Associations between amyloid and tau pathology, and connectome alterations, in Alzheimer's disease and mild cognitive impairment
J King-Robson, H Wilson, M Politis… - Journal of …, 2021 - content.iospress.com
Background: The roles of amyloid-and tau in the degenerative process of Alzheimer's
disease (AD) remain uncertain.[18F] AV-45 and [18F] AV-1451 PET quantify amyloid-and …
disease (AD) remain uncertain.[18F] AV-45 and [18F] AV-1451 PET quantify amyloid-and …
Tau-related grey matter network breakdown across the Alzheimer's disease continuum
W Pelkmans, R Ossenkoppele, E Dicks… - Alzheimer's Research & …, 2021 - Springer
Background Changes in grey matter covariance networks have been reported in preclinical
and clinical stages of Alzheimer's disease (AD) and have been associated with amyloid-β …
and clinical stages of Alzheimer's disease (AD) and have been associated with amyloid-β …
Age and sex-related effects on single-subject gray matter networks in healthy participants
Y Shigemoto, N Sato, N Maikusa, D Sone… - Journal of Personalized …, 2023 - mdpi.com
Recent developments in image analysis have enabled an individual's brain network to be
evaluated and brain age to be predicted from gray matter images. Our study aimed to …
evaluated and brain age to be predicted from gray matter images. Our study aimed to …
Neuroimaging within the dominantly inherited Alzheimer's network (DIAN): PET and MRI
Abstract The Dominantly Inherited Alzheimer Network (DIAN) Observational Study is an
international collaboration studying autosomal dominant Alzheimer disease (ADAD). This …
international collaboration studying autosomal dominant Alzheimer disease (ADAD). This …
Disrupted single-subject gray matter networks are associated with cognitive decline and cortical atrophy in Alzheimer's disease
Background Research has shown disrupted structural network measures related to cognitive
decline and future cortical atrophy during the progression of Alzheimer's disease (AD) …
decline and future cortical atrophy during the progression of Alzheimer's disease (AD) …
Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer's disease continuum
Background: Large-scale neuronal network breakdown underlies memory impairment in
Alzheimer's disease (AD). However, the differential trajectories of the relationships between …
Alzheimer's disease (AD). However, the differential trajectories of the relationships between …
Axonal damage and astrocytosis are biological correlates of grey matter network integrity loss: a cohort study in autosomal dominant Alzheimer disease
L Vermunt, C Sutphen, E Dicks, DM de Leeuw… - medRxiv, 2023 - medrxiv.org
Brain development and maturation leads to grey matter networks that can be measured
using magnetic resonance imaging. Network integrity is an indicator of information …
using magnetic resonance imaging. Network integrity is an indicator of information …